(De-)stabilizing change

Stabilizing and Destabilizing Processes of Change. Insights from Brain and Software Development

Processes of change are a central phenomenon in various scientific disciplines, such as physics, biology, and business administration. These processes often unfold along trajectories. For example, due to the laws of physics, a toy car begins to move when we place it on a sloped wooden track until it reaches the lower platform. The wooden track functions here as a trajectory that stabilizes the toy car’s movement along the track. However, under certain circumstances, destabilization can occur, causing the toy car to derail or become wedged in the track. We find similar mechanisms in many change processes, though these are often more complex than in the example of the toy car.

The goal of the project “Stabilizing and destabilizing processes of change – Insights from brain and software development” is therefore to gain new insights into the stabilizing and destabilizing mechanisms of change processes. To this end, the interdisciplinary project draws on two different case studies from the life sciences and business administration. The first case study examines the developmental process of the human brain. This process is defined by a genetically determined blueprint; however, external influences, such as medications, can destabilize the process. The second case study examines the process of change in work routines within software development. The case study identifies stabilizing mechanisms that lead to an exact replication of an existing team’s work routines, as well as mechanisms that lead to a destabilization of the change process.

By combining the two case studies, the project identifies stabilizing and destabilizing mechanisms of change processes that can be generalized across disciplines. These insights are relevant to a wide range of academic disciplines as well as management practice. Thus, this project explores in detail which mechanisms keep the toy cars on the track and what causes them to deviate from the planned route.

Funded by

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Workshop: “Interdisciplinary Perspectives on Change”

September 21 and 22, 2023, at the HAdW.

Program and registration:

https://www.hadw-bw.de/news/events/interdisciplinary-perspectives-change

Invitation to the Workshop “Interdisciplinary Perspectives on Change” on September 21 and 22, 2023

As part of our WIN project “(De-)stabilizing change,” we are hosting an international workshop on “Interdisciplinary Perspectives on Change” on September 21 and 22, 2023. We are delighted to have succeeded in bringing together outstanding scholars from various disciplines who will share their experiences with us. Professor Hans-Jörg Rheinberger of the Max Planck Society will deliver a keynote address. In addition, Professor Britta Nestler (KIT), Professor Robin Hiesinger (FU Berlin), and Professor Brian Pentland (Michigan State University) will participate in a panel discussion reflecting on the topic of change. The goal of the workshop is to stimulate an interdisciplinary exchange on processes of change.

Hans-Jörg Rheinberger is a research fellow of the Max Planck Society and former director of the Max Planck Institute for the History of Science in Berlin. He is also a member of the Leopoldina. His work focuses on the history and epistemology of experimentation in the life sciences. Britta Nestler is the director of the Institute for Applied Materials—Microstructure Modeling and Simulation and of the Microstructure Simulation Division at the Institute for Nanotechnology at the Karlsruhe Institute of Technology. In a dual role, she is also director of the Institute for Digital Materials Research at Karlsruhe University of Applied Sciences and a full member of the Heidelberg Academy of Sciences and Humanities. Her work focuses on computer-aided materials science, particularly microstructure simulation in the field of materials engineering. Her research has been honored with numerous scientific Awards, including the Gottfried Wilhelm Leibniz Prize from the German Research Foundation (DFG). Robin Hiesinger studied biology and philosophy and is a professor at Freie Universität Berlin. He investigates the mechanisms of neural network formation in fruit flies and is currently focusing, as part of an ERC project, on how flexibility and robustness can be ensured during development. Brian Pentland is the Main Street Capital Corporation Intellectual Capital Professor at Michigan State University. His work lies at the intersection of organizational theory and business informatics and focuses in particular on the study of organizational routines and processes.

With this in mind, we cordially invite you to participate in our workshop. You can find the preliminary program and the registration form at the following link: https://www.hadw-bw.de/news/events/interdisciplinary-perspectives-changenews/events/interdisciplinary-perspectives-change

If you have any questions or suggestions, please feel free to contact us at christian.mahringer@bwi.uni-stuttgart.de.

With warm regards,

Simone Mayer and Christian Mahringer

WIN Fellows
Project Staff
  • Zeynep Yentür, Research Associate
  • Lisa Albicker, Research Assistant
  • Felix Hildebrand, Student Assistant
  • Christina Kulka, Research Assistant
  • Laura Schmiedle, Research Assistant

  1. Kagermeier, T., Hauser, S., Sarieva, K., Laugwitz, L., Groeschel, S., Janzarik, W. G., Yentür, Z., Becker, K., Schöls, L., Krägeloh-Mann, I., & Mayer, S. (2024). Human organoid model of pontocerebellar hypoplasia 2a recapitulates brain region-specific size differences. Disease Models & Mechanisms, 17(7).
  2. Kutscher, L. M., Aprile, D., Bayin, N. S., Becker, E. B. E., Cerrato, V., Turrini, G., Coolen, M., Cantagrel, V., Durand, B. C., Evans II, M. K., Haldipur, P., Millen, K. J., Yeung, J., Goldowitz, D., Hatten, M. E., Joyner, A. L., Kebschull, J. M., Li, J. Y. H., Quadrato, G., … Mayer, S. (2025). Conference report: Cerebellar development and disease at single-cell resolution. Cerebellum, 24(4), 109.
  3. Mahringer, C. A. (2022). Analyzing digital trace data to promote discovery. The case of heatmapping. Lecture Notes in Business Information Processing, 436, 209–220.
  4. Mahringer, C. A. (2024). Innovating as chains of interrelated situations. Scandinavian Journal of Management, 40(1), 1–8.
  5. Mahringer, C. A., Baessler, F., Gerchen, M. F., Haak, C., Jacob, K., & Mayer, S. (2023). Benefits and obstacles of interdisciplinary research. Insights from members of the Young Academy at the Heidelberg Academy of Sciences and Humanities. iScience, 26(12), 1–6.
  6. Mahringer, C. A., Danner-Schröder, A. (In press). Autonomous, yet interdependent. Designing interfaces across routine clusters. Academy of Management Journal.
  7. Mahringer, C. A., Mayer, S. (2023). Understanding Change: The Relevance of Conceptual Clarity. Athene – Magazine of the HAdW, 1.
  8. Mahringer, C. A., Schmiedle, L., Albicker, L., & Mayer, S. (2025). The iceberg model of change. A taxonomy differentiating approaches to change. Heliyon, 11(2), 1–10.
  9. Mahringer, C. A., & Walleser, N. (2023). How process models change business processes in organizations. From planned to emergent change. In Proceedings of the European Conference on Information Systems.
  10. Sarieva, K., Hildebrand, F., Kagermeier, T., Yentür, Z., Becker, K., & Mayer, S. (2023). Pluripotent stem cell-derived neural progenitor cells can be used to model the effects of IL-6 on human neurodevelopment. Disease Models & Mechanisms, 16(11).
  11. Sarieva, K., Kagermeier, T., Khakipoor, S., Atay, E., Yentür, Z., Becker, K., & Mayer, S. (2023). A human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable. Molecular Psychiatry, 1–13.
  12. Sarieva, K., Kagermeier, T., Lysenkov, V., Yentür, Z., Becker, K., Matilainen, J., Casadei, N., & Mayer, S. (2024). Comparing the impact of sample multiplexing approaches for single-cell RNA-sequencing on downstream analysis using cerebellar organoids. bioRxiv.
  13. Sarieva, K., & Mayer, S. (2021). The effects of environmental adversities on human neocortical neurogenesis modeled in brain organoids. Frontiers in Molecular Biosciences, 8, 686410.
  14. Yentür, Z., Kagermeier, T., Sarieva, K., Jarboui, M. A., Becker, K., & Mayer, S. (2025). Human dorsal forebrain organoids show differentiation-state-specific protein secretion. iScience, 28(7), 112935.
  15. Yentür, Z., Sarieva, K., Branco, L., Kagermeier, T., Kulka, C., Jarboui, M. A., Becker, K., & Mayer, S. (2025). Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and the cellular microenvironment in dorsal forebrain organoids. bioRxiv.
Dr. Simone Mayer

Eberhard Karls University of Tübingen
Otfried-Müller-Straße 27
72076 Tübingen

si.mayer@uni-tuebingen.de

Dr. Christian Mahringer

University of Stuttgart
Keplerstraße 17
70174 Stuttgart

christian.mahringer@bwi.uni-stuttgart.de